Systematic reviews of diagnostic test accuracy.

TitleSystematic reviews of diagnostic test accuracy.
Publication TypeJournal Article
Year of Publication2008
AuthorsLeeflang MMG, Deeks JJ, Gatsonis C, Bossuyt PMM
Corporate AuthorsCochrane Diagnostic Test Accuracy Working Group
JournalAnnals of internal medicine
Date Published2008 Dec 16
KeywordsDiagnostic Tests, Routine; Humans; Information Storage and Retrieval; Meta-Analysis as Topic; Research Design; Review Literature as Topic; ROC Curve; Sensitivity and Specificity

More and more systematic reviews of diagnostic test accuracy studies are being published, but they can be methodologically challenging. In this paper, the authors present some of the recent developments in the methodology for conducting systematic reviews of diagnostic test accuracy studies. Restrictive electronic search filters are discouraged, as is the use of summary quality scores. Methods for meta-analysis should take into account the paired nature of the estimates and their dependence on threshold. Authors of these reviews are advised to use the hierarchical summary receiver-operating characteristic or the bivariate model for the data analysis. Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research.

Alternate JournalAnn. Intern. Med.