Joan.Vlayen
History
- Member for
- 9 years 28 weeks
Related content
- Book page
- ADAPTE (GCP)
- 1. Introduction
- 3. Deciding on important outcomes
- 3.5. Expert involvement
- 5. Rating the quality of evidence
- 5.1. Introduction
- 5.1.2. Overall quality of evidence
- 5.1.3. GRADE and meta-analysis
- 5.2. Study limitations, risk of bias
- 5.3. Inconsistency
- 5.3.1. Heterogeneity and inconsistency
- 5.3.2. Judging heterogeneity and inconsistency
- 5.3.3. Other considerations
- 5.4. Indirectness
- 5.5. Imprecision
- 5.5.1. Clinical decision threshold and minimally important difference
- 5.5.1.1. Categorical outcomes
- 5.5.1.2. Continuous outcomes
- 5.5.2. Application and examples
- 5.5.3. Relative versus absolute reductions
- 5.5.4. Dealing with fragility: Optimal Information Size (OIS)
- 5.5.5. Low event rates with large sample size: an exception to the need for OIS
- 5.6. Publication bias
- 5.7. Reasons to upgrade studies
- 5.7.1. Large magnitude of effect
- 5.7.3. Dose-response gradient
- 6. Recommendations
- 6.1. Four key factors influence the strength of a recommendation
- 6.2. Wording of a recommendation
- The ADAPTE methodology
- 5. Searching for evidence on adverse effects
- 3.6. Use of surrogates
- 3.8. Adverse effects
- 5.1.1. Four levels of evidence
- 5.2.1. Risk of bias assessment of individual studies should be done using a validated assessment tool
- 5.2.2. Moving from individual risk of bias to a judgment about rating down for risk of bias across a body of evidence
- ADAPTE: To use or not to use?
- 2. Building a search question
- 3.6.1 Search tools
- 3.6 Building a search strategy
- 1.2. Limitations of GRADE
- 1.3. Steps in the process
- 2. Framing the question
- 3.1. General approach
- 3.2. Perspective of outcomes
- 3.3. Before and after literature review
- 3.4. Implications of the classification
- 3.7. Clinical decision threshold and minimally important difference
- 4. Summarizing the evidence
- 3.4 Sources of ongoing clinical trials
- 3.6.2 Search limits
- 3.6.3. Search filters
- 3.7 Documenting a search strategy
- 4. Searching supplementary sources
- 1.1. What is GRADE?
- 1. Introduction
- 7.3. Critical appraisal of diagnostic accuracy studies
- 7.5. Critical appraisal of guidelines
- 7.2. Critical appraisal of randomized controlled trials for interventions
- 8. Data extraction
- GRADE evidence profiles
- 7. Quality assessment of studies
- 7.4. Critical appraisal of observational studies
- Evidence tables
- GUIDELINE DEVELOPMENT: PRINCIPLES (GCP)
- 3.3 Sources of clinical practice guidelines
- 3.5. Sources of grey literature
- SEARCH FOR EVIDENCE (GCP - HTA)
- 3.2 Sources of economic literature
- 7. GRADE and diagnostic testing
- 3.1 Sources of biomedical literature
- 3. Searching electronic sources
- WORDING OF RECOMMENDATIONS - TIPS AND TRICKS
- WHICH TYPE OF RECOMMENDATIONS?
- FORMULATION OF CLINICAL RECOMMENDATIONS (GCP)