Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force.

TitleGrading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force.
Publication TypeJournal Article
Year of Publication2006
AuthorsGuyatt G, Gutterman D, Baumann MH, Addrizzo-Harris D, Hylek EM, Phillips B, Raskob G, Lewis SZ, Sch├╝nemann H
JournalChest
Volume129
Issue1
Pagination174-81
Date Published2006 Jan
ISSN0012-3692
KeywordsAdvisory Committees; Evidence-Based Medicine; Humans; Practice Guidelines as Topic; Pulmonary Medicine; Quality Assurance, Health Care; United States
Abstract

While grading the strength of recommendations and the quality of underlying evidence enhances the usefulness of clinical guidelines, the profusion of guideline grading systems undermines the value of the grading exercise. An American College of Chest Physicians (ACCP) task force formulated the criteria for a grading system to be utilized in all ACCP guidelines that included simplicity and transparency, explicitness of methodology, and consistency with current methodological approaches to the grading process. The working group examined currently available systems, and ultimately modified an approach formulated by the international GRADE group. The grading scheme classifies recommendations as strong (grade 1) or weak (grade 2), according to the balance among benefits, risks, burdens, and possibly cost, and the degree of confidence in estimates of benefits, risks, and burdens. The system classifies quality of evidence as high (grade A), moderate (grade B), or low (grade C) according to factors that include the study design, the consistency of the results, and the directness of the evidence. For all future ACCP guidelines, The College has adopted a simple, transparent approach to grading recommendations that is consistent with current developments in the field. The trend toward uniformity of approaches to grading will enhance the usefulness of practice guidelines for clinicians.

URLhttp://www.chestjournal.org.vdicp.health.fgov.be:8080/cgi/pmidlookup?view=long&pmid=16424429
Alternate JournalChest