APPENDIX 1: EXAMPLE OF PICO

Choice β blocker
A patient diagnosed with hypertension and admitted for a laparoscopic knee surgery, asks you whether Tenormin, the antihypertensive drug he is taking, is better than Selozok, the one his neighbour is taking.

Patient / population patient with hypertension
Intervention atenolol
Comparison metoprolol
Outcomes (cardiovascular) mortality