Evaluating the role of quality assessment of primary studies in systematic reviews of cancer practice guidelines.

TitleEvaluating the role of quality assessment of primary studies in systematic reviews of cancer practice guidelines.
Publication TypeJournal Article
Year of Publication2005
AuthorsBrouwers MC, Johnston ME, Charette ML, Hanna SE, Jadad AR, Browman GP
JournalBMC medical research methodology
Volume5
Issue1
Pagination8
Date Published2005 Feb 16
ISSN1471-2288
KeywordsBlood Transfusion; Clinical Trials as Topic; Confidence Intervals; Humans; Needs Assessment; Neoplasms; Odds Ratio; Practice Guidelines as Topic; Quality Assurance, Health Care; Review Literature as Topic; Sensitivity and Specificity
Abstract

BACKGROUND: The purpose of this study was to evaluate the role of study quality assessment of primary studies in cancer practice guidelines.

METHODS: Reliable and valid study quality assessment scales were sought and applied to published reports of trials included in systematic reviews of cancer guidelines. Sensitivity analyses were performed to evaluate the relationship between quality scores and pooled odds ratios (OR) for mortality and need for blood transfusion.

RESULTS: Results found that that whether trials were classified as high or low quality depended on the scale used to assess them. Although the results of the sensitivity analyses found some variation in the ORs observed, the confidence intervals (CIs) of the pooled effects from each of the analyses of high quality trials overlapped with the CI of the pooled odds of all trials. Quality score was not predictive of pooled ORs studied here.

CONCLUSIONS: Had sensitivity analyses based on study quality been conducted prospectively, it is highly unlikely that different conclusions would have been found or that different clinical recommendations would have emerged in the guidelines.

DOI10.1186/1471-2288-5-8
Alternate JournalBMC Med Res Methodol